Breaking from BBC
When the Senior most military person makes a bold statement like this, he has credible evidence.
Since the US SEAL Team 6 operation near Pakistan's "West Point" killed Osama Bin Laden, US-Pakistani relations have degraded and will now likely degrade further.
Adm. Mullen's comments include stating evidence shows Pakistani Intelligence (ISI), have been involved in multiple smaller but effective operations. This does not portend well for future relations between Pakistan and the United States.
More importantly, it affirms belief that the ISI had stronger connections to Osama Bin Laden than expected. Pakistani involvement in attacks on US and NATO troops in Kabul, also speaks to lack of respect for US prestige and power.
This is yet another policy issue that is sure to dog Pres. Obama, both in policy adjustment and in his overall lack of a strong Foreign and Military Policy.